Bt maize technology involves developing hybrid maize crops that incorporate genes from the soil-dwelling bacteria Bacillus thuringiensis (Bt). The primary benefit of Bt maize technology is the heightened crop protection from stem borers, which are maize pests that can inflict serious crop losses. Bt maize has been cultivated in Mexico, South Africa and several countries in the European Union, with limited cultivation in Sub-Saharan Africa (SSA). This report provides a summary of literature on the potential benefits and challenges associated with Bt maize production in SSA. Research studies of Bt maize in the Philippines and South Africa are also briefly reviewed. There is little peer-reviewed literature available, with evidence challenging the assumed benefits of Bt maize for smallholder farmers in SSA. As a result, we also review research briefs and conference proceedings available from reputable international organizations. Although some of the available literature references the ethical concerns over Bt maize production, we focus on searching for science-based discussions related to any potential biodiversity, biosafety, or socio-economic impacts of Bt maize technology for smallholder farmers in SSA.