Local crop diversity and crop cultivation patterns among smallholder farmers have implications for two important elements of the design of agricultural interventions in developing countries. First, crop cultivation patterns may aid in targeting by helping to identify geographic areas where improved seed and other productivity enhancing technologies will be most easily applicable. Second, these patterns may help to identify potential unintended consequences of crop interventions focused on a single crop (e.g. maize). This report analyzes the distribution of crop diversity and crop cultivation patterns, and factors that can lead to changes in these patterns among smallholder farmers in Tanzania with a focus on regional patterns of crop cultivation and changes in these patterns over time, the factors that affect crop diversity and changes in crop diversity, and the level of substitutability between crops grown by smallholder farmers. All analysis is based on the Tanzania National Panel Survey (TNPS) datasets from 2008 and 2010. The paper is structured as follows. Section I provides a description of regional patterns of crop cultivation and crop diversity between the two years of the panel. Section II presents background on the theoretical factors affecting crop choice, and presents our findings on the results of a multivariate analysis on the factors contributing to crop diversity. Finally, Section 3 provides a preliminary analysis of the level of substitutability between cereal crop of importance in Tanzania (maize, rice and sorghum/millet) and also between these cereal crops and non-cereal crops.