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The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.
This annotated bibliography addresses agricultural transformation and mechanization, dietary diversification and energy needs, and conservation tillage. Each citation is accompanied by an annotation briefly describing the findings and key takeaways.
This literature review provides information on the dynamics of the maize market and maize prices in Zambia. We address four key topics: average production costs and breakeven prices for maize farmers in Zambia, main drivers of volatility of maize production volumes, key factors driving the differences between Zambian and global maize prices, and policies that may have contributed to increased farmer productivity.
Smallholder farmers in Africa are largely located in poor rural areas, are often geographically dispersed, and have limited access to road and communication infrastructure, thus raising the cost of market participation. This is especially true for farmers growing relatively low value staple crops. This literature review summarizes research on the challenges and innovations in linking smallholder producers of staple grains to markets in Sub-Saharan Africa, with a focus on post-harvest issues including storage, aggregation, and transportation. For each post-harvest stage, we describe challenges faced by farmers and current efforts to address these challenges. In our review, we find a large amount of literature on the constraints to smallholder production and marketing but relatively few examples of innovative or novel technologies designed to improve storage and transportation for rural smallholder producers in Africa. Existing technologies have often been available for some time but have not seen widespread adoption, apparently due to high costs or inadequate funding for on-farm testing and extension. We conclude that the literature is somewhat divided as to whether interventions linking smallholder farmers to markets should be entirely market-driven and focus on linkages that can be profitable without subsidization, or whether NGO- and donor-driven interventions should play a role.
This report provides a general overview of trends in public and private agricultural research and development (R&D) funding and expenditures in Sub-Saharan Africa (SSA). The request is divided into two sections, covering public funding and private funding. Within each section, relevant data is presented on historical funding patterns, the types of research conducted, and which countries within SSA are financing R&D at the highest level. We find that the majority of growth in African public agricultural research funding took place in the 1960s, when real public spending on agricultural research increased 6% a year. From 1971 to 2000 annual growth averaged 1.4% a year. Public financing of agricultural R&D experienced a moderate shift in the 1990s from bilateral and multilateral donor funding to domestic government financing. The shift varied by country, but donor funding dropped for all SSA countries an average of 10%. Private research and development funding is heavily concentrated in developed countries with the United States and Japan the two biggest spenders. Within SSA, private R&D expenditures comprise 2% of all R&D spending. The main private actors in SSA are companies based in South Africa and Nigeria. The private sector is focused on research areas that involve marketable inputs, such as chemicals, seeds, and machines/
Special Economic Zones (SEZs) are generally defined as geographically delimited areas administered by a single body, offering certain incentives (duty-free importing and streamlined customs procedures, for instance) to businesses that physically locate within the zone. This literature review provides a baseline analysis of SEZs and their potential impacts on smallholder farmers in SSA. Criticism on SEZs is distinctly divided between those who criticize on social or environmental grounds versus those who question the economic impact of SEZs. SEZs are often criticized based on perceived negative socio-economic impacts—particularly their negative impact on women, labor, and working conditions. This review includes several country-specific studies that find evidence that SEZs actually have higher environmental standards and higher worker satisfaction than outside the SEZ. Most responses to criticisms do note, however, that the case studies’ results are not necessarily generalizable to SEZs throughout the world. The literature review includes key elements of successes and failures pulled from the case studies of SEZs in SSA. Though the evidence is insufficient to conclusively determine if smallholder farmers receive direct benefits from SEZs and their associated agroindustrial contracts, this review finds that resources provided to farmers (credit at rates lower than bank rates, technical or managerial assistance, pesticides, seeds, and fertilizer on credit) tend to be concentrated among larger farmers. The report concludes with a note on donor involvement as well as recommendations for further research.