Populations

Geography

Dataset

EPAR RESEARCH BRIEF #386
Evidence of Observed Climate Impacts on Smallholder Farmer Systems
Publication Date: 05/08/2019
Type: Research Brief
Abstract

In many countries in Sub-Saharan Africa and South Asia smallholder farmers are among the most vulnerable to climatic changes, and the observed shocks and stresses associated with these changes impact agricultural systems in many ways. This research brief offers findings on observed or measured changes in precipitation, temperature or both, on five biophysical pathways and systems including variable or changing growing seasons, extreme events, biotic stressors, plant species density, richness and range, impacts to streamflow, and impacts on crop yield. These findings are the result of a review of relevant documents cited in Kilroy (2015), references included in the IPCC draft Special Report on Food Security, and targeted searches from 2015 - present for South Asia and Sub-Saharan Africa. 

Results Coding, Research Brief
EPAR Technical Report #346
Assessing Pharma’s Constraints, Opportunities, and Investment Options in Global Health R&D: An Analysis of SEC 10-K Filings
Publication Date: 04/23/2018
Type: Literature Review
Abstract

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

Executive Summary, Full Report