Types of Research

EPAR Technical Report #346
Publication Date: 04/23/2018
Type: Literature Review

The private sector is the primary investor in health research and development (R&D) worldwide, with investment annual investment exceeding $150 billion, although only an estimated $5.9 billion is focused on diseases that primarily affect low and middle-income countries (LMICs) (West et al., 2017b). Pharmaceutical companies are the largest source of private spending on global health R&D focused on LMICs, providing $5.6 billion of the $5.9 billion in total private global health R&D per year. This report draws on 10-K forms filed by Pharmaceutical companies with the U.S. Securities and Exchange Commission (SEC) in the year 2016 to examine the evidence for five specific disincentives to private sector investment in drugs, vaccines and therapeutics for global health R&D: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed costs for research and manufacturing, and imperfect markets. 10-K reports follow a standard format, including a business section and a risk section which include information on financial performance, investment options, lines of research, promising acquisitions and risk factors (scientific, market, and regulatory). As a result, these filings provide a valuable source of information for analyzing how private companies discuss risks and challenges as well as opportunities associated with global health R&D targeting LMICs.

EPAR Technical Report #329
Publication Date: 05/31/2017
Type: Literature Review

This research considers how public good characteristics of different types of research and development (R&D) and the motivations of different providers of R&D funding affect the relative advantages of alternative funding sources. We summarize the public good characteristics of R&D for agriculture in general and for commodity and subsistence crops in particular, as well as R&D for health in general and for neglected diseases in particular, with a focus on Sub-Saharan Africa and South Asia. Finally, we present rationales for which funders are predicted to fund which R&D types based on these funder and R&D characteristics. We then compile available statistics on funding for agricultural and health R&D from private, public and philanthropic sources, and compare trends in funding from these sources against expectations. We find private agricultural R&D spending focuses on commodity crops (as expected). However contrary to expectations we find public and philanthropic spending also goes largely towards these same crops rather than staples not targeted by private funds. For health R&D private funders similarly concentrate on diseases with higher potential financial returns. However unlike in agricultural R&D, in health R&D we observe some specialization across funders – especially for neglected diseases R&D - consistent with funders’ expected relative advantages.

EPAR Technical Report #331
Publication Date: 06/20/2016
Type: Data Analysis

Labor is one of the most productive assets for many rural households in developing countries. Despite the importance of labor—and time use more generally—little research has empirically examined the quality of time-use data in household surveys. Many household surveys rely on respondent recall, the reliability of which may decrease as recall length increases. In addition, respondents often report on time allocation for the entire household, which they may not know or recall as clearly as their own time allocation. Finally, simultaneous activities such as tending children while preparing dinner, may lead to the systematic underestimation of certain activities, particularly those that tend to be performed by women. This paper examines whether the identity of the survey respondent affects estimates of time allocation within the household. Drawing on the Ugandan LSMS-ISA household survey, we find that individuals responding for themselves report higher levels of time use over the previous week than when responding for other household members. Moreover, male respondents tend to underreport time allocation for females over the age of 15 as compared to female respondents, especially time spent on domestic activities. In addition, an analysis of the effects of two economics shocks—having a baby and floods or droughts—suggests that the identity of the respondent can affect substantive conclusions about the effects of shocks on household time use.