Types of Research
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The share of private sector funding, relative to public sector funding, for drug, vaccine, and diagnostic research & development (R&D) differs considerably across diseases. Private sector investment in overall health R&D exceeds $150 billion annually, but is largely concentrated on non-communicable chronic diseases with only an estimated $5.9 billion focused on "global health", targeting diseases that primarily affect low and middle-income countries (LMICs). We examine the evidence for five specific disincentives to private sector global health R&D investment: scientific uncertainty, weak policy environments, limited revenues and market uncertainty, high fixed and sunk costs, and downstream rents from imperfect markets. Though all five may affect estimates of net returns from an investment decision, they are worth examining separately as each calls for a different intervention or remediation to change behavior.
Cash transfer programs are interventions that directly provide cash to target specific populations with the aim of reducing poverty and supporting a variety of development outcomes. Low- and middle-income countries have increasingly adopted cash transfer programs as central elements of their poverty reduction and social protection strategies. Bastagli et al. (2016) report that around 130 low- and middle-income countries have at least one UCT program, and 63 countries have at least one CCT program (up from 27 countries in 2008). Through a comprehensive review of literature, this report primarily considers the evidence of the long-term impacts of cash transfer programs in low- and lower middle-income countries. A review of 54 reviews that aggregate and summarize findings from multiple studies of cash transfer programs reveals largely positive evidence on long-term outcomes related to general health, reproductive health, nutrition, labor markets, poverty, and gender and intra-household dynamics, though findings vary by context and in many cases overall conclusions on the long-term impacts of cash transfers are mixed. In addition, evidence on long-term impacts for many outcome measures is limited, and few studies explicitly aim to measure long-term impacts distinctly from immediate or short-term impacts of cash transfers.
The concept of global public goods represents a framework for organizing and financing international cooperation in global health research and development (R&D). Advances in scientific and clinical knowledge produced by biomedical R&D can be considered public goods insofar as they can be used repeatedly (non-rival consumption) and it is difficult or costly to exclude non-payers from gaining access (non-excludable). This paper considers the public good characteristics of biomedical R&D in global health and describes the theoretical and observed factors in the allocation R&D funding by public, private, and philanthropic sources.
This literature review examines the environmental impacts of water buffalo in pastoral and mixed farming systems in Sub-Saharan Africa, South Asia, and South America). The environmental impacts of water buffalo are less widely studied than those of the other livestock species included in this series; typically, the environmental impacts of water buffalo are incorporated into discussions of cattle without more detailed impacts being broken down by bovine type. In Asia and India, where the majority of buffalo are raised, buffalo are typically kept in small herds of only a few animals, which may minimize the local impacts of their grazing on vegetation, soil erosion and water pollution. Some aspects of buffalo feeding and life cycle patterns, as observed in the Amazon, may cause their greenhouse gas emissions to differ from those of cattle: buffalo can fatten on a wider range of grasses, reach market size in a shorter time, transition better from dry to wet seasons, and are more resistant to bovine diseases. While buffalo grazing and trampling can lead to land degradation, buffalo can contribute to nutrient and resource cycling in farming systems because their manure is considered good fertilizer and they can remove and utilize biomass grown on agricultural plots. Mitigation strategies vary by category of environmental impact, but largely suggest improved productivity to reduce land conversion, modified management systems (e.g., biodiversity, water use and consumption, farm and pastures, and waste), and the reduction of livestock numbers altogether.
This literature review examines the environmental impacts of cattle in pastoral and mixed farming systems in Sub-Saharan Africa and South Asia. Cattle are frequently cited as having the most severe overall environmental impacts among livestock species due to: methane and nitrous oxide released from digestion and manure; land use and conversion; desertification; inefficient ratio of weight of feed and water consumed to weight of meat and dairy produced; conflicts between livestock herders and wildlife; the large volume of wastewater produced in meat and hide processing; and overgrazing of riparian areas. However, cattle have also been found to provide several environmental benefits such as keeping wildlife corridors open, preventing the spread of noxious weeds, and promoting the growth of local vegetative species. Mitigation strategies vary by category of environmental impact, but largely suggest improved productivity to reduce land conversion, modified management systems (e.g., biodiversity, water use and consumption, farm and pastures, grain and other feed, and waste), and the reduction of livestock numbers altogether.
This literature review examines the environmental impacts of goats in pastoral and mixed farming systems in Sub-Saharan Africa and South Asia. We find that the most notable environmental implications of goats stem from their ability to graze on a wide variety of biomass sources in frequently marginal environments; while this intensive grazing stimulates biodiversity loss and may be more severe than grazing by other livestock species, goats are not a major driver of forest clearing due to their low economic value. Environmental benefits of goat production include keeping wildlife corridors open, preventing the spread of noxious weeds, and promoting the growth of local vegetative species through moderate grazing. Goats are also more water-efficient than large ruminants such as cattle. Mitigation strategies vary by category of environmental impact, but largely suggest improved productivity to reduce land conversion, modified management systems (e.g., biodiversity, water use and consumption, grazing intensity and frequency, and waste), and the reduction of livestock numbers altogether.
This literature review examines the environmental impacts of chickens in pastoral and mixed farming systems in Sub-Saharan Africa and South Asia. Compared to ruminant species (cattle, water buffalo, and goats), chickens produce lower carbon dioxide, methane, and nitrous oxide emissions, are a less significant driver of human expansion into natural habitat or of overgrazing, have lower impacts on the water cycle, and cause less destruction of natural habitats. Poultry’s major impacts on land degradation result from the production of their grain-intensive feed. Chicken production also poses a threat to avian biodiversity, as chickens are susceptible to viruses and act as vectors of disease transmission to avian wildlife. Chicken manure is widely viewed as a valuable fertilizer in developing countries, although transportation costs limit manure sales in local markets and the high nitrogen-phosphorous ratio can impact certain soils and water. Mitigation strategies vary by category of environmental impact, but largely suggest modified management systems (e.g., biodiversity, health, livestock feed efficiency, and waste).
This report combines analyses from four previous EPAR briefs on the effects of climate change on maize, rice, wheat, sorghum, and millet production in Sub-Saharan Africa (SSA). In addition, this brief presents new analysis of the projected impact of climate changes in SSA. We include comparisons of the importance of each crop, of their vulnerability to climate change, and of the research and policy resources dedicated to each. Especially with respect to climatic susceptibility, these rankings provide a comparative summary based upon the analysis conducted in the four previous EPAR briefs, statistical analyses of historical yield and climate data, and future climate model predictions. According to the indicators analyzed, our research suggests that maize leads the cereal crops in terms of importance within SSA and in terms of research and policy attention. Our analysis of climate conditions and the crop’s physical requirements suggests that many maize-growing areas are likely to move outside the range of ideal temperature and precipitation conditions for maize production. Rice is the third most important crop in terms of consumption dependency, fourth in terms of production, but second only to maize in terms of research funding and FTEs. Sorghum and millet rank second and third in production importance and second and fifth in consumption importance, but rank below maize and rice in terms of FTE researchers. Their role is complicated by the fact that they are often considered inferior goods; SSA consumers often substitute away from sorghum and millet consumption if they are able to do so. Wheat is the least-produced crop of the five, and the second to last in terms of consumption importance. However, it still ranks above millet in terms of FTE researchers.
This brief reviews the literature and empirical evidence on waste extraction and treatment in the developing world. The brief assesses the quantity and quality of research supporting key components of program theory related to the extraction of sludge from on-site sanitation facilities and pre-disposal transport. In general, we find few empirical studies that directly evaluate the assertions of the program theory. Most of the evidence in the literature that addresses the target components of program theory is based upon case studies or general observational and experiential assertions by sanitation experts. Where appropriate, we have identified evidence in the literature according to whether case studies or informal observations formed the basis of the conclusion.
The purpose of this literature review is to provide qualitative and quantitative examples of technologies, constraints and incentives for efficient waste treatment and reuse in Sub-Saharan Africa and Southeast Asia. We present relevant case studies and expert observations and experiences on the nutrient content in urine and feces, contaminants frequently found in untreated sludge and wastewater, waste treatment technologies that may be relevant for low-income countries, risks associated with waste reuse, benefits to resource recovery in agriculture. We further discuss reasons for waste treatment failures, including urbanization, observations on challenges with market-driven reuse in less developed countries, and examples of net-positive energy facilities in Europe and the United States. Much of the evidence presented in the literature relates to wastewater treatment processes or the sludge produced from wastewater treatment as opposed to untreated fecal sludge. However, examples of risks, failures, and opportunities for raw sludge treatment and reuse are discussed when available. In some cases, empirical evidence or case studies were not available for developing countries and alternatives are presented. Overall we found the empirical evidence on waste treatment and reuse in developing countries is quite thin.